ApplyBlast uses AI to match you with the right jobs, tailor your resume and cover letter, and apply automatically so you can land your dream job faster.

Features

Auto Apply Resume Optimizer Cover Letter Optimizer Interview Prep

Company

Social Media

Need Help?

team@applyblast.com

Director - Molecular Dynamics at Eli Lilly and Company - ApplyBlast

Director - Molecular Dynamics

Eli Lilly and Company

3 days ago

4.0 on Glassdoor

South San Francisco, California, United States

Onsite

Full Time

Director

0 applicants

View Job Listing

Apply to 100+ jobs

About this role

Lilly's RNA Therapeutics organization is seeking a computational biophysicist to establish atomic-resolution models of how chemical modifications affect siRNA guide strand loading into Argonaute 2. The role involves building molecular dynamics and free-energy models to predict how modification patterns impact loading, passenger-strand release, and catalytic efficiency, ultimately providing design rules for medicinal chemists. This position requires leading a team of senior computational scientists while maintaining close collaboration with chemistry, structural biology, and biochemistry teams.

Responsibilities

Build molecular dynamics and free-energy models of Ago2 guide-strand complexes
Run all-atom and enhanced-sampling simulations of siRNA duplexes and RISC loading intermediates
Convert simulation output into testable structure-activity hypotheses for medicinal chemists

Skills

Qualifications

PhD in biophysics, computational chemistry, chemical physics, structural biology or a related STEM field

About Eli Lilly and Company

lilly.com

Headquarters

Indianapolis, Indiana, United States

Company Size

10001+ employees

Founded

1876

View Profile

Eli Lilly and Company is a global biopharmaceutical company headquartered in Indianapolis, Indiana. It discovers, develops, manufactures and commercializes prescription medicines across therapeutic areas including diabetes, oncology, immunology, neuroscience and pain, and has a longstanding history in insulin and other major drug discoveries. Lilly invests heavily in research and clinical development and partners with biotech, academic institutions, and industry collaborators to advance biologics, small molecules, and precision medicines. The company operates global manufacturing and commercial networks and provides patient-support programs to improve access to its therapies.