Principal Scientist, Antibody Engineering & Rational Design
Calico
About this role
The Principal Scientist will bridge computational design and experimental validation within Calico’s antibody discovery engine, acting as the scientific liaison between wet-lab teams and machine learning groups. The role advances a rational, data-driven Design-Build-Test-Learn cycle to translate in silico designs into developable biologic therapeutics. The scientist will lead projects that integrate experimental and computational research to improve model-driven discovery outcomes.
Skills
Qualifications
About Calico
calicolabs.comCalico (Calico Life Sciences LLC) is an Alphabet-backed research and development company focused on understanding the biology of aging and translating that knowledge into interventions to extend healthy lifespan. The company combines large-scale biology, genetics, chemistry and computational approaches to discover targets, biomarkers and potential therapies for age-related diseases. Calico works through multi‑disciplinary teams and collaborations with academic and industry partners to move fundamental discoveries toward clinical impact.
Recent company news
BioSpaceAbbVie Ends 11-Year Relationship With Calico, Lays Off 100+
Nov 13, 2025
NatureCalico, Alphabet’s anti-ageing play, goes it alone
Dec 12, 2025
Fierce BiotechAlphabet's Calico stitches $596M deal for Mabwell's anti-aging asset
Jun 26, 2025
New York PostGold rush returns to California as thousands descend on tiny ghost town
2 weeks ago
The New York TimesSued for Playing With Toys?
Aug 7, 2025
About Calico
Headquarters
San Francisco, CA
Company Size
201-500 employees
Founded
2018
Industry
Technology
Glassdoor Rating
4.2 / 5
Leadership Team
Sarah Johnson
Chief Executive Officer
Michael Chen
Chief Technology Officer
Emily Williams
VP of Engineering
David Rodriguez
VP of Product
Jessica Thompson
Chief Financial Officer
Andrew Park
VP of Sales
Unlock Company Insights
View leadership team, funding history,
and employee contacts for Calico .
Salary
$198k – $241k
per year
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