Principal Scientist, Antibody Engineering & Rational Design

Calico (1 month ago)

South San Francisco, CAOnsiteFull TimeSenior$198,000 - $241,000Research & Development

About this role

The Principal Scientist will bridge computational design and experimental validation within Calico’s antibody discovery engine, acting as the scientific liaison between wet-lab teams and machine learning groups. The role advances a rational, data-driven Design-Build-Test-Learn cycle to translate in silico designs into developable biologic therapeutics. The scientist will lead projects that integrate experimental and computational research to improve model-driven discovery outcomes.

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Required Skills

Antibody Engineering
Protein Engineering
Structural Modeling
ML Design
Experimental Validation
Data Generation
Affinity Maturation
Humanization
Multispecific Antibodies
Biophysical Characterization

+4 more

Qualifications

Ph.D. in Molecular Biology, Biochemistry, Computational Modeling, Structural Biology, or Related Discipline

About Calico

calicolabs.com

Calico (Calico Life Sciences LLC) is an Alphabet-backed research and development company focused on understanding the biology of aging and translating that knowledge into interventions to extend healthy lifespan. The company combines large-scale biology, genetics, chemistry and computational approaches to discover targets, biomarkers and potential therapies for age-related diseases. Calico works through multi‑disciplinary teams and collaborations with academic and industry partners to move fundamental discoveries toward clinical impact.