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Principal Scientist, Process Development (Expression Systems) at Moderna - ApplyBlast

Principal Scientist, Process Development (Expression Systems)

Moderna

5 months ago

3.2 on Glassdoor

Norwood, Massachusetts

Hybrid

Full Time

Senior

0 applicants

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About this role

A Principal Scientist in Process Development at Moderna leads the strategy for E. coli-based production of recombinant enzymes and plasmids. The role involves designing expression systems, executing screening workflows, and translating small-scale data into scalable process development plans. This position requires deep expertise in microbial genetics, molecular biology, and data-driven construct selection to support the company's technology platforms.

Responsibilities

Lead host strain and vector strategy for E. coli production systems
Design and execute high-throughput screening cascades for production candidates
Optimize fermentation workflows and define stage-appropriate decision criteria
Translate small-scale screening data into scalable process development leads
Mentor technical teams and serve as a leader in expression system design

Skills

Qualifications

PhD in Molecular Biology, Microbiology, Chemical Engineering, Biotechnology, or Synthetic BiologyMS in related discipline with 10+ years experienceBS in related discipline with 12+ years experience

About Moderna

modernatx.com

Headquarters

Cambridge, Massachusetts, United States

Company Size

1001-5000 employees

Founded

2010

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Moderna is a biotechnology company that is pioneering the use of mRNA technology to develop transformative medicines and vaccines. It gained global prominence for its COVID-19 vaccine, which showcased the potential of mRNA in rapidly addressing public health emergencies. The company is focused on creating innovative therapies to treat a range of diseases, advancing its product pipeline, and exploring new career opportunities in the biotech field. With a commitment to changing the landscape of medicine, Moderna is at the forefront of scientific research and development.