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Process Dev Engineering Principal Scientific Associate at Vertex - ApplyBlast

Process Dev Engineering Principal Scientific Associate

Vertex

3 months ago

3.7 on Glassdoor

Boston, MA

Onsite

Full Time

Senior

1 applicant

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About this role

A Principal Scientific Associate in Process Development Engineering at Vertex leads the development and optimization of upstream and downstream production processes for cell and gene therapy projects. The role involves executing bench-scale experiments, applying Design of Experiments (DoE) and Quality by Design (QbD) principles, and transferring processes to commercial manufacturing environments. This position requires deep expertise in stem cell culture, aseptic techniques, and regulatory documentation to support clinical and commercial milestones.

Responsibilities

Support development of scaled upstream and downstream production processes for cell therapy
Perform stem cell expansion and differentiation in bench-scale bioreactors
Apply DoE and QbD principles to establish process parameters and optimize methods
Transfer processes to internal manufacturing and CDMOs for scale-up implementation
Draft study protocols, reports, and regulatory filings ensuring data integrity