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Scientist I, Formulations at Flagship Pioneering, Inc. - ApplyBlast

Scientist I, Formulations

Flagship Pioneering, Inc.

4 months ago

Remote

Full Time

Senior

1 applicant

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About this role

A Senior Dried Powder Formulation Scientist at Flagship Pioneering supports the development, screening, and optimization of dried powder formulations using techniques such as lyophilization and spray drying, contributing to experimental design, data interpretation, and best practices for formulation screening, characterization, and documentation in a fast-moving, early-stage environment.

Responsibilities

Design, execute, and optimize dried powder formulations using lyophilization and spray drying, with a focus on stability, reproducibility, and performance across multiple formulation variables.
Execute formulation screening efforts using statistically grounded experimental designs (e.g., DoEs), including selection of factors, responses, and experimental conditions, and translate results into actionable next steps.
Evaluate the impact of excipients, processing conditions, and storage environments on material stability, integrity, and functionality, including under accelerated or stress conditions.
Characterize dried powder products using appropriate analytical and physical methods (e.g., particle size and morphology, thermal analysis, moisture content, bulk properties) to inform formulation and process decisions.
Support process development and scale-awareness by documenting critical parameters, identifying sources of variability, and generating data relevant to future scale-up, tech transfer, or external partnerships.

Skills

Qualifications

Bachelor’s degree (with 10 years of relevant research experience) or Master’s degree (with 8 years of relevant research experience) in chemistry, chemical engineering, pharmaceutical sciences, materials science, biotechnology, or a related discipline.Demonstrated experience with drying-based formulation techniques, including lyophilization and/or spray drying, and an understanding of how process parameters influence solid-state properties.Strong grounding in physical chemistry or materials science principles relevant to dried systems, including glass transition behavior, crystallinity, moisture interactions, and excipient effects.Experience designing and executing statistically informed experiments (e.g., DoEs), with the ability to interpret interaction effects and use data to guide experimental iteration.Familiarity with analytical and characterization techniques for powders and solid-state materials (e.g., DSC, TGA, particle sizing, microscopy, bulk property measurements), and the ability to select fit-for-purpose methods.

About Flagship Pioneering, Inc.

flagshippioneering.com

Headquarters

Cambridge, Massachusetts, United States

Company Size

201-500 employees

Founded

2000

View Profile

Flagship Pioneering is a venture creation and investment firm that invents, builds, and funds early-stage companies in biotechnology, life sciences, and sustainability. Using an integrated model of in-house science, lab infrastructure, capital, and operational support, it spins out and scales breakthrough ventures — it has helped found more than 100 companies, including high-profile names such as Moderna. Flagship focuses on deep‑science innovation and long‑term partnerships to translate novel discoveries into transformative products for human health and the planet.