Senior Principal Research Scientist, Medicinal Chemistry

Vertex is seeking a Senior Principal Research Scientist, Medicinal Chemistry to provide scientific leadership in the design and optimization of small-molecule therapeutics across discovery programs. This on-site role involves advancing high-quality drug candidates from early discovery through candidate selection while partnering with multidisciplinary teams to solve complex scientific challenges. The ideal candidate will bring deep expertise in small-molecule drug discovery and a strong record of scientific innovation.