Senior / Principal Scientist, Structural Biology

Flagship Pioneering, Inc.(7 days ago)

United States, Cambridge, MAOnsiteFull TimeSenior$126,000 - $214,500Research and Development

About this role

A Senior/Principal Scientist, Structural Biologist at Expedition Medicines focuses on determining protein-ligand complex structures using X-ray crystallography and cryo-EM to support drug discovery efforts. The role operates within an early-stage biotechnology company pioneering protein editing to enable novel therapeutic modalities and works closely with project teams to inform structure-based design.

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Required Skills

X-ray Crystallography
Cryo-EM
Protein Purification
Construct Design
Grid Preparation
Data Analysis
Structure Refinement
CRO Management
Structure-Based Design
Biophysical Methods

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Qualifications

PhD in Structural Biology, Biochemistry, Molecular Biology, or Related Field
MS in Structural Biology, Biochemistry, Molecular Biology, or Related Field

About Flagship Pioneering, Inc.

flagshippioneering.com

Flagship Pioneering is a venture creation and investment firm that invents, builds, and funds early-stage companies in biotechnology, life sciences, and sustainability. Using an integrated model of in-house science, lab infrastructure, capital, and operational support, it spins out and scales breakthrough ventures — it has helped found more than 100 companies, including high-profile names such as Moderna. Flagship focuses on deep‑science innovation and long‑term partnerships to translate novel discoveries into transformative products for human health and the planet.