Principal Program Manager, Drug Discovery (Medicinal Chemistry and DMPK)
Calico
About this role
The Drug Discovery Principal Program Manager will drive advancement of Calico’s preclinical drug discovery pipeline from hit generation to clinical candidate nomination. The role coordinates complex, multidisciplinary projects executed largely through external CROs, ensuring on-time, on-budget delivery while maintaining scientific and compliance standards. The position serves as the central hub for communication, planning, and execution across internal and external stakeholders to support robust pipeline operations.
Skills
Qualifications
About Calico
calicolabs.comCalico (Calico Life Sciences LLC) is an Alphabet-backed research and development company focused on understanding the biology of aging and translating that knowledge into interventions to extend healthy lifespan. The company combines large-scale biology, genetics, chemistry and computational approaches to discover targets, biomarkers and potential therapies for age-related diseases. Calico works through multi‑disciplinary teams and collaborations with academic and industry partners to move fundamental discoveries toward clinical impact.
Recent company news
AbbVie Ends 11-Year Relationship With Calico, Lays Off 100+
Nov 13, 2025
Calico, Alphabet’s anti-ageing play, goes it alone
Dec 12, 2025
Alphabet's Calico stitches $596M deal for Mabwell's anti-aging asset
Jun 26, 2025
Gold rush returns to California as thousands descend on tiny ghost town
2 weeks ago
Sued for Playing With Toys?
Aug 7, 2025
About Calico
Headquarters
San Francisco, CA
Company Size
201-500 employees
Founded
2018
Industry
Technology
Glassdoor Rating
4.2 / 5
Leadership Team
Sarah Johnson
Chief Executive Officer
Michael Chen
Chief Technology Officer
Emily Williams
VP of Engineering
David Rodriguez
VP of Product
Jessica Thompson
Chief Financial Officer
Andrew Park
VP of Sales
Unlock Company Insights
View leadership team, funding history,
and employee contacts for Calico .
Salary
$188k – $200k
per year
More jobs at Calico
Similar Jobs
Principal Scientist, Drug Discovery
MSD
Scientific Vice President, Lead Discovery & Optimization
0468 BMS Polska Sp. z o.o.
Principal Scientist, Medicinal Chemistry
Neurocrine Biosciences
Medicinal Chemist, Drug Discovery
Brigham and Women's Hospital
Principal Scientist - Medicinal Chemistry
Amgen
Executive Director, DMPK
Neurocrine Biosciences