Manifold Bio
Manifold Bio is developing AI models for protein therapeutic design, utilizing high-throughput experimental data and computational methods. The company combines protein engineering with AI-driven discovery to create advanced biologics, employing a multidisciplinary approach involving molecular biology, automation, and machine learning.
Manifold Bio is a biotech company that designs tissue-targeted medicines directly in vivo. They built a high-throughput in vivo (HTV) discovery engine that combines massively multiplexed in‑animal screening with AI‑powered design to discover and optimize targeted biologics. The platform enables engineering of tissue- and cell-type‑specific delivery modalities (for example, next‑generation brain shuttles) and supports strategic partnerships with pharma. Their approach aims to accelerate discovery and increase translational success for targeted biologic therapeutics.
Roche signs $2B pact to pilot Manifold Bio's shuttles to the brain
Nov 3, 2025
Manifold Bio Expands Leadership Team to Drive its AI + In Vivo Targeted Biologics Platform
Dec 16, 2025
Manifold Bio Expands Leadership Team to Drive its AI + In Vivo Targeted Biologics Platform
Dec 15, 2025
Headquarters
San Francisco, CA
Company Size
201-500 employees
Founded
2018
Industry
Technology
Glassdoor Rating
4.2 / 5
Sarah Johnson
Chief Executive Officer
Michael Chen
Chief Technology Officer
Emily Williams
VP of Engineering
David Rodriguez
VP of Product
Jessica Thompson
Chief Financial Officer
Andrew Park
VP of Sales
View leadership team, funding history,
and employee contacts for Manifold Bio.
Manifold Bio didn’t post a salary, so this is our estimate from similar listings.
18% above the average for this role
Roche taps an AI specialist to craft new brain drugs
Nov 3, 2025
Senior Research Associate, High-Throughput Protein Binder Screening
Digital Biology
Senior Science and People Lead in Bioconjugation and Protein Engineering (m/f/d)
Roche
Postdoctoral Associate
Scripps Research
Sr Director, Protein Biochemistry and Lab Automation
Gilead Sciences
Cell Culture Development Intern
R&D Systems
Principal/ Senior Scientist – T Cell Engager & Multispecific Protein Engineering
PharmaEssentia